From History: From 251.902 to 66.0 million years ago.
The Mesozoic era starts with the end-Permian mass extinction 252 million years ago. Dinosaurs ruled over all, including us. It ends the reign of dinosaurs with the K–Pg extinction 66 million years ago.
From History: ~1 Billion years ago (+/- 200 million)
About 1 billion years ago, giant viruses evolved by “hoarding” cellular genes, expanding their genomes until they blurred the line between a simple virus and a living cell.
From History: ~3.2 Billion Years Ago (+/- 200 million)
Around the time of the first bacteria, about 3.2 billion years ago and after LUCA, the Duplodnaviria evolved a high-pressure, icosahedral protein armor that turned viruses into biological syringes capable of injecting DNA into any domain of life.
From History: ~2.75 Billion years ago (+/- 200 million)
About 2.75 billion years ago, the Varidnaviria evolved a unique “Double Jelly-Roll” protein fold to build massive, diverse shells, allowing viruses to scale up from tiny parasites to “giant” viruses that mimic cells.
From History: ~1.75 Billion years ago (+/- 200 million)
About 1.75 billion years ago, Monodnaviria evolved as “runaway” genetic loops (plasmids) that stole structural proteins from other viruses to become independent, single-stranded DNA parasites.
From History: 251,902,000 years ago (+/- 900 years).
The Permian-Triassic extinction was not just the end of many species. It was a planetary reset that destroyed the old synapsid-dominated world and opened the door for the archosaur line that would later give rise to dinosaurs.
From History: ~1.25 Billion years ago (+/- 200 million)
About 1.25 billion years ago, Retroviruses emerged by transforming “jumping genes” into infectious agents, mastering the ability to rewrite a host’s permanent genetic code.