Long before the complexity of full-fledged nervous systems, elaborate senses, and brains, life on Earth developed the basic ability to perceive and react to mechanical stimuli—a process known as cellular mechanosensitivity. A contemporary manifestation of this can be observed in the movement of some plants today, such as the Venus flytrap, which responds to touch by snapping shut to capture prey. This early form of proto-sensing, relying on signal transduction pathways within single-celled organisms, represents the precursor to the sophisticated sensory and nervous systems found in later multicellular life. Through mechanisms like ion channel activation and signal transduction cascades, these primitive organisms could respond to touch and pressure, paving the way for the evolutionary journey towards more advanced forms of perception. This foundational stage of sensory evolution, occurring as early as 800 million years ago, underscores the deep biological roots of our ability to sense and interact with the world around us.