First Life: Self-Replicating Molecules

Weekly Insights for Thinkers

Science • Philosophy • Critical Thinking • History • Politics • RW • AI • Physics • Evolution • Astronomy • 30 Phil Book • More…

Science • Phil • Cr. Think • Hist • …

STORY

First Life: Self-Replicating Molecules

By Michael Alan Prestwood

Mon 1 Apr 2024

Published 2 years ago.

Updated 6 days ago.

Pre-LUCA Evolution

First Life: Self-Replicating Molecules

4.2 Billion years ago (+/- 200 million)

Self-replication emerges

The appearance of self-replicating molecules, such as RNA or similar nucleic acid analogues, signified a monumental leap towards life. These molecules had the ability to store genetic information and catalyze their own replication, laying the foundational mechanism for heredity and evolution by natural selection, driving the complexity forward towards the emergence of life as we understand it. While none survive today, viruses are an interesting related non-life thing. Another interesting and related thing in modern life are plasmids and transposons. In bacteria and some other organisms, these DNA molecules replicate independently of the host’s chromosomal DNA. While they are part of complex cellular life and rely on the cell’s machinery for replication, their ability to replicate independently echoes the autonomy of early self-replicating molecules.

Domain: Pre-domain or none > Kingdom: Not applicable

Life on Earth: The 5th threshold is life on Earth.

— map / TST —

Michael Alan Prestwood
Author & Natural Philosopher

Prestwood writes on science-first philosophy, with particular attention to the convergence of disciplines. Drawing on his TST Framework, his work emphasizes rational inquiry grounded in empirical observation while engaging questions at the edges of established knowledge. With TouchstoneTruth positioned as a living touchstone, this work aims to contribute reliable, evolving analysis in an emerging AI era where the credibility of information is increasingly contested.